OK, if you get the admittedly much tougher follow-up question as to why you were let go (and the truth isn't exactly pretty), your best bet is to be honest (the job-seeking world is small, after all). But it doesn't have to be a deal-breaker. Share how you’ve grown and how you approach your job and life now as a result. If you can position the learning experience as an advantage for this next job, even better.

Tip: Employers often ask this question to identify why you might be more qualified than other candidates they’re interviewing. To answer, focus on why hiring you would benefit the employer. Since you don’t know the other applicants, it can be challenging to think about your answer in relation to them. Addressing why your background makes you a good fit will let employers know why your traits and qualifications make you well prepared.
Example: “What I liked most about my last position the ability contribute in a collaborative way with other teams. Each team member was encouraged to bring new ideas to the project which were respectfully considered by all. For example, we once worked with a client who was relying on us to solve a critical issue. Our team met to discuss the situation. After I recommended a plan to resolve the issue, we took time considering the pros and the cons of the solution, building on how to make the idea better and more comprehensive. When we implemented it, it worked better and faster than everyone expected. The client was very pleased.”
Of course, if you have an issue that is very important to you that could be a deal-breaker (like company culture), you can mention it. Just be prepared for them to take one extreme or the other. For example, maybe you only want to work for companies that buy from vendors in your home country. The hiring manager will let you know if their company does this. And if they don’t, I guess the interview is over.
However, after I landed my first job as a content writer, it became clear that while this process worked for me (I’ve never missed a deadline), it made my editor extremely nervous. And so I’ve learned to set “early” deadlines for myself, at least 24 hours before the actual deadline, so that my projects now always arrive with plenty of time to spare. 
You won't be asked a hundred questions at a job interview, but it's completely understandable if you feel overwhelmed looking at this list. Just know this: Nobody expects you to have all the answers—that's what the experts at Monster are for. Still have questions about the hiring process? Join Monster today. As a member, you'll get career advice and useful tips sent directly to your inbox. From resume-writing checklists to lists of companies hiring to how to get promoted, Monster will help you plot an awesome career path, one step at a time. 
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