They fired me because I had a different opinion than the director of the company. Nothing wrong with him—we just had a different philosophy of leadership, and how things should be done. Maybe he was right, maybe I was—only time will tell. But I do not want to live in the past. Now I am here, looking for a new challenge, and an opportunity to help your company to prosper.
Don't be thrown off by this question—just take a deep breath and explain to the hiring manager why you've made the career decisions you have. More importantly, give a few examples of how your past experience is transferrable to the new role. This doesn't have to be a direct connection; in fact, it's often more impressive when a candidate can make seemingly irrelevant experience seem very relevant to the role.
Laid off is not fired: If you were part of a layoff, this is different from being fired. It was likely a financial decision by management, and you were part of a group that was targeted as part of budget cuts. Layoffs are typically not personal -- they are just business. Hiring managers know this (and likely have been involved in one at some point in their careers).
Interview Questions What Makes You Unique?
Any candidate can read and regurgitate the company’s “About” page. So, when interviewers ask this, they aren't necessarily trying to gauge whether you understand the mission—they want to know whether you care about it. Start with one line that shows you understand the company's goals, using a couple key words and phrases from the website, but then go on to make it personal. Say, “I’m personally drawn to this mission because…” or “I really believe in this approach because…” and share a personal example or two.